Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic
substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors …

Background In humans, bitterness perception is mediated by~ 25 bitter taste receptors
present in the oral cavity. Among these receptors three, TAS2R10, TAS2R14 and TAS2R46 …

Although bitter taste receptors (TAS2Rs) are important for human health, little is known of the
determinants of ligand specificity. TAS2Rs such as TAS2R16 help define gustatory …

Scope To avoid ingestion of potentially harmful substances, humans are equipped with
about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells. Humans exhibit …

A family of 25 G protein–coupled receptors, TAS2Rs, mediates bitter taste in humans. Many
of the members of this family are coexpressed in a subpopulation of taste receptor cells on …

The recognition of potentially harmful food components by the gustatory system is important
for survival and well-being of vertebrates. The plethora of structurally diverse bitter …

Bitter taste receptors (TAS2Rs) mediate aversive response to toxic food, which is often bitter.
These G‐protein‐coupled receptors are also expressed in extraoral tissues, and emerge as …

Bitter taste perception is initiated by TAS2R receptors, which respond to agonists by
triggering depolarization of taste bud cells. Mutations in TAS2Rs are known to affect taste …

Sensing potentially harmful bitter substances in the oral cavity is achieved by a group of˜ 25
receptors, named TAS 2Rs, which are expressed in specialized sensory cells and recognize …

Bitter taste receptors (TAS2Rs) function in taste perception, but are also expressed in many
extraoral tissues, presenting attractive therapeutic targets. TAS2R5s expressed on human …