Inflammasomes are cytosolic multiprotein signaling complexes that are activated upon
pattern recognition receptor-mediated recognition of pathogen-derived ligands or …

Guanylate-binding proteins (GBPs) are essential components of cell-autonomous immunity.
In response to IFN signaling, GBPs are expressed in the cytoplasm of immune and …

Inflammasomes are cytosolic signaling complexes capable of sensing microbial ligands to
trigger inflammation and cell death responses. Here, we show that guanylate-binding …

Innate immunity responds to pathogens by producing alarm signals and activating pathways
that make host cells inhospitable for pathogen replication. The intracellular bacterium …

The immune system is armed with a broad range of receptors to detect and initiate the
elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a …

Traditional views of the inflammasome highlight the assembly of pre-existing core
components shortly after infection or tissue damage. Emerging work, however, suggests that …

Host recognition of intracellular bacterial pathogens results in the formation of a multiprotein
complex termed the inflammasome, which leads to the recruitment and activation of …

The inflammasome is essential for host defense against intracellular bacterial pathogens,
including Legionella pneumophila, the causative agent of the severe pneumonia …

Abstract Inflammatory caspase‐11 (rodent) and caspases‐4/5 (humans) detect the Gram‐
negative bacterial component LPS within the host cell cytosol, promoting activation of the …

Guanylate binding proteins (GBPs) are interferon-inducible proteins involved in the cell-
intrinsic immunity against numerous intracellular pathogens. The molecular mechanisms …