Cancer is a leading cause of death in both adults and children, but in terms of absolute
numbers, pediatric cancer is a relatively rare disease. The rarity of pediatric cancer is …

Improvements in protocol-driven clinical trials and supportive care for children and
adolescents with cancer have reduced mortality rates by more than 50% over the past three …

Oncologists and cancer biologists are frequently confronted by the question of what causes
cancer? This is particularly vexing for cancers affecting children and young adults who have …

Four out of five children diagnosed with cancer can be cured with contemporary cancer
therapy. This represents a dramatic improvement since 50 years ago when the cure rate of …

Purpose This report provides an overview of current childhood cancer statistics to facilitate
analysis of the impact of past research discoveries on outcome and provide essential …

The past decade has witnessed a major increase in our understanding of the genetic
underpinnings of childhood cancer. Genomic sequencing studies have highlighted key …

Background It is estimated that 300,000 children 0–19 years of age are diagnosed with
cancer worldwide each year (1). In high-income countries, cancer is the leading cause of …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Cancer is the leading disease-related cause of death in children in developed countries.
Arising in the context of actively growing tissues, childhood cancers are fundamentally …

One explanation for the relative lack of progress in treating cancer in adolescents and young
adults is that the biology of malignant diseases in this age group is different than in younger …