[HTML][HTML] Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies

K Azuma, S Yamanaka - Regenerative Therapy, 2016 - Elsevier
In Japan, a research center network consisting of Kyoto University to provide clinical-grade
induced Pluripotent Stem Cells (iPSC) and several major research centers to develop iPSC …

Modeling blood diseases with human induced pluripotent stem cells

M Georgomanoli… - Disease Models & …, 2019 - journals.biologists.com
Induced pluripotent stem cells (iPSCs) are derived from somatic cells through a
reprogramming process, which converts them to a pluripotent state, akin to that of embryonic …

In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells

N Takayama, K Eto - Platelets and Megakaryocytes: Volume 3, Additional …, 2012 - Springer
Human embryonic stem cells (hESCs) represent a potential source of blood cells for
transfusion therapies and a promising tool for studying the ontogeny of hematopoiesis …

[HTML][HTML] Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells

S Ohmine, AB Dietz, MC Deeds, KA Hartjes… - Stem cell research & …, 2011 - Springer
Introduction The induced pluripotent stem cell (iPSC) technology allows generation of
patient-specific pluripotent stem cells, thereby providing a novel cell-therapy platform for …

[HTML][HTML] Induced pluripotent stem cells and personalized medicine: current progress and future perspectives

YS Chun, K Byun, B Lee - Anatomy & cell biology, 2011 - ncbi.nlm.nih.gov
Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of
regenerative medicine by providing researchers with a unique tool to derive disease-specific …

[HTML][HTML] Application of mesenchymal stem cells derived from human pluripotent stem cells in regenerative medicine

TM Liu - World Journal of Stem Cells, 2021 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) represent the most clinically used stem cells in
regenerative medicine. However, due to the disadvantages with primary MSCs, such as …

[HTML][HTML] Hurdles to clinical translation of human induced pluripotent stem cells

E Neofytou, CG O'Brien, LA Couture… - The Journal of clinical …, 2015 - Am Soc Clin Investig
Human pluripotent stem cells are known to have the capacity to renew indefinitely, being
intrinsically able to differentiate into many different cell types. These characteristics have …

[PDF][PDF] A manually curated database on clinical studies involving cell products derived from human pluripotent stem cells

S Kobold, A Guhr, N Mah, N Bultjer, S Seltmann… - Stem cell reports, 2020 - cell.com
The last 5 years have witnessed a significant increase in the number of clinical studies
based on human pluripotent stem cells (hPSCs). In parallel, concern is increasing about the …

[HTML][HTML] A Defined, Feeder-Free, Serum-Free System to Generate In Vitro Hematopoietic Progenitors and Differentiated Blood Cells from hESCs and hiPSCs

G Salvagiotto, S Burton, CA Daigh, D Rajesh, II Slukvin… - PloS one, 2011 - journals.plos.org
Human ESC and iPSC are an attractive source of cells of high quantity and purity to be used
to elucidate early human development processes, for drug discovery, and in clinical cell …

Do human leukocyte antigen-typed cellular therapeutics based on induced pluripotent stem cells make commercial sense?

CA Bravery - Stem cells and development, 2015 - liebertpub.com
The promise of off-the-shelf cellular therapeutics (CTPs) based on allogeneic induced
pluripotent stem cells (iPSCs) may be hindered by alloimmunity, leading many to suggest …