Publisher Summary This chapter reviews the most representative data accumulated in
recent years that strongly suggest:(1) the resemblance between many cancerous and …

The close relationship at the molecular level between cellular differentiation and neoplasia
has been evidenced by the discovery in adult individuals of fetospecific antigens and fetal …

The tendency for malignancies to lose the final differentiated morphology of their tissue of
origin (ie to dedifferentiate) was recognized some 150 years ago (cf. Ref. 1); more than 30 …

Cancer is discussed from a standpoint of a postembryonic differentiation. A differentiation
requires the interaction of an exogenous inductive stimulus with competent precursor cell …

The resemblance between neoplastic and embryonic tissues has attracted the attention of
biologists for more than a century because of its apparent physiopathological implications …

This book contains 18 selections. Some of the titles are: Exploring Carcinogenesis with
Retroviral and Cellular Oncogenes; Retroviruses, Oncogenes and Evolution; HTLV and …

Publisher Summary The chapter discusses the normal stem-cell systems, evidence for the
aberrant developmental nature of tumors, first through examples of spontaneous …

Cellular genes whose expression can be associated with the transformed phenotype were
first recognized as coopted cellular genes inserted by transduction into retroviral genomes …

Current medical literature acknowledges that embryonic micro-environment is able to
suppress tumor development. Administering carcinogenic substances during organogenesis …

Publisher Summary The chapter examines the theory that cancer is a disease of the
mechanism of differentiation and that the compositional and behavioral changes observed …