DNA methylation is a mammalian epigenetic mark that participates to define where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

The DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine are the most
successful epigenetic drugs to date and are still the most widely used as epigenetic …

The pharmacological inhibition of DNA methyltransferases provides novel opportunities for
the therapy of human cancers. Several Phase III trials of DNA methyltransferase inhibitors …

Although chemotherapy is considered the mainstay of cancer therapy, unfortunate side
effects of chemotherapy create a continuous demand for developing other novel and specific …

Methylation of DNA at 5-position of cytosine, catalyzed by DNA methyltransferases, is the
predominant epigenetic modification in mammals. Aberrations in methylation play a causal …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

Epigenetics refers to partially reversible, somatically inheritable, but DNA sequence-
independent traits that modulate gene expression, chromatin structure, and cell functions …

Epimutations, such as the hypermethylation and epigenetic silencing of tumor suppressor
genes, play a role in the etiology of human cancers. In contrast to DNA mutations, which are …

DNA methylation is a mammalian epigenetic mark that is involved in defining where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

DNA methylation mediated by DNA methyltransferase is an important epigenetic process
that regulates gene expression in mammals, which plays a key role in silencing certain …