Choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter
acetylcholine (ACh), is thought to be present in kinetic excess in cholinergic neurons. The …

In cholinergic neurons, the presynaptic choline transporter (CHT) mediates high-affinity
choline uptake (HACU) as the rate-limiting step in acetylcholine (ACh) synthesis. It has …

Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity
choline transporter CHT is essential for providing choline as substrate for synthesis of …

Functional variation in the gene encoding the presynaptic choline transporter (CHT) has
been linked to attention-deficit/hyperactivity disorder. Here, we report that a heterozygous …

Cholinergic neurons elaborate a hemicholinium‐3 (HC‐3) sensitive choline transporter
(CHT) that mediates presynaptic, high‐affinity choline uptake (HACU) in support of …

Synthesis, storage and release of acetylcholine (ACh) require the expression of several
specialized enzymes, including choline acetyltransferase (ChAT), vesicular acetylcholine …

The cholinergic neurons have long been a model for biochemical studies of
neurotransmission. The components responsible for cholinergic neurotransmission, such as …

Supplementation of maternal diet with the essential nutrient, choline, during the second half
of pregnancy in rats causes long-lasting improvements in spatial memory in the offspring …

An important feature of cholinergic neurons is high-affinity choline transport, which allows
them to reuse choline for the synthesis of ACh needed to support cholinergic …

Cholinergic projections to the cortex and hippocampus mediate fundamental cognitive
processes. The capacity of the high-affinity choline uptake transporter (CHT) to import …