Early revascularization of pancreatic islet cells after transplantation is crucial for engraftment,
and it has been suggested that vascular endothelial growth factor-A (VEGF-A) plays a …

Aims/hypothesis The initial avascular period following islet transplantation seriously
compromises graft function and survival. Enhancing graft revascularisation to improve …

Rapid and adequate revascularization of transplanted islets is important for their survival
and function during transplantation. Vascular endothelial growth factor (VEGF) could play a …

Background. Delayed angiogenesis remains a significant challenge to the survival of
transplanted islets. In this study, using a murine model of subcutaneous islet transplantation …

Aims/hypothesis Vascular endothelial growth factor (VEGF) has been recognised by loss-of-
function experiments as a pleiotropic factor with importance in embryonic pancreas …

Background. Vascular endothelial growth factor (VEGF) and its two receptor tyrosine
kinases, Flk-1/KDR and Flt-1, may play an important role in mediating the revascularization …

Islet transplantation is limited by islet graft failure due to poor revascularization, host immune
rejection and nonspecific inflammatory response. Delivery of human vascular endothelial …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

For gene transfer strategies to improve islet engraftment, vascular endothelial growth factor
(VEGF) expression should be regulated in a way that matches the transient nature of …

Background. Blood flow is impaired in islet transplants, but there is conflicting evidence on
improving the outcome by promoting vascularization. We previously reported that islet …