Objective SIRT1 is known to inhibit apoptosis and to promote survival of various types of
cells. However, the roles of SIRT1 in apoptosis of human chondrocytes have never been …

Objective To analyse the expression of SIRT1 in synovial tissues and cells of patients with
rheumatoid arthritis (RA) and to study the function of SIRT1 in inflammation and apoptosis in …

Objective We previously demonstrated that Sirt1 regulates apoptosis in cartilage in vitro.
Here we attempt to examine in vivo cartilage homeostasis, using Sirt1 total body knockout …

Abstract Objective The protein deacetylase SirT1 inhibits apoptosis in a variety of cell
systems by distinct mechanisms, yet its role in chondrocyte death has not been explored. We …

In this study, we examined the effects of overexpression of SIRT1 on IL‐1β‐induced gene
expression changes in human chondrocytes to explore a protective role of SIRT1 in human …

Sirt1 involved in cellular aging and aging-related diseases, including osteoarthritis (OA). Our
previous study showed Sirt1 played a role in the pathogenesis of OA, however, the …

SIRT1 has been implicated as a key factor in aging‐related diseases. Nevertheless, the role
of SIRT1 in the pathogenesis of osteoarthritis (OA) is still unknown. We examined the …

Osteoarthritis (OA) is the most common form of joint disease. The aim of this study was to
explore the functions of SIRT3 on OA pathophysiology and the mechanism involved. Rat …

Sirtuins have been involved in the osteoarthritis (OA) process. However, the functions of
SIRT4 in the degeneration of human chondrocytes and OA are not fully understood. This …

Objective We and others previously demonstrated that sirtuin 1 (SIRT‐1) regulates apoptosis
and cartilage‐specific gene expression in human chondrocytes and mouse models. This …