Gastrointestinal adenocarcinoma (GIA) is a common malignant disease worldwide. Its
tumorigenesis and progression is a multistage process with the involvement of a …

Simple Summary Enhancer of zeste homolog 2 (EZH2) modifies the trimethylation of Lys-27
of histone 3, affecting downstream target genes' expression. It was reported that EZH2 is …

Despite the mounting studies exploring the role of estrogen receptor alpha (ERα), estrogen
receptor beta (ERβ) and androgen receptor (AR) in gastric cancer (GC), there remain …

AIM: To investigate the relationship between expression of p21 WAF1 and p53 gene, and to
evaluate the deletion and polymorphism of p21 WAF1 gene in gastric carcinoma (GC) …

Aims: Mutations in the gene coding for p53 protein are among the most frequent genetic
alterations observed in human cancers. The relevance and biological significance of p53 …

Alterations of cell cycle-regulated genes play an important role in the process of
carcinogenesis, and some of them are thought to be prognostic factors in esophageal …

Alterations of polycomb group (PcG) genes directly modulate the trimethylation of histone H3
lysine 27 (H3K27me3) and may thus affect the epigenome of hepatocellular carcinoma …

We aimed to assess protein expressions of p16 and pRB in breast cancer and explore the
clinicopathologic implications. Tissue microarray (TMA) was constructed with 406 cases of …

Background STAT3 signaling plays the pivotal role in tumorigenesis through EZH2
epigenetic modification, which enhanced STAT3 activity by increased tyrosine …

AIM: To further understand the molecular basis for gastric cardia carcinogenesis and to
provide etiological clues. METHODS: Endoscopic mucosa biopsy and histopathological …