[HTML][HTML] Apixaban is safe and effective in morbidly obese patients: a retrospective analysis of 390 patients with BMI≥ 40

Y Choi, M Kushnir, HH Billett - Blood, 2017 - Elsevier
Background: In patients with venous thromboembolism (VTE), warfarin had been considered
standard of care until the new direct oral anticoagulants (DOACs) were developed. Studies …

Comparative effectiveness and safety of direct oral anticoagulants in obese patients with atrial fibrillation

A Briasoulis, A Mentias, A Mazur, P Alvarez… - … drugs and therapy, 2021 - Springer
Background Unlike warfarin direct oral anticoagulants (DOACs) are administered in fixed
doses, which raises concerns of its effectiveness on larger patients. Data from randomized …

Prescribing DOACs with specific patient populations in mind.

K Schleich, BE Ray - Journal of Family Practice, 2023 - search.ebscohost.com
The article focuses on the prescribing considerations of direct oral anticoagulants (DOACs)
for specific patient populations, including those with obesity, renal disease, cancer, and …

[HTML][HTML] Peak plasma concentration of direct oral anticoagulants in obese patients weighing over 120 kilograms: a retrospective study

S Piran, H Traquair, N Chan, V Bhagirath… - Research and practice …, 2018 - Elsevier
Background Due to a paucity of data on the efficacy and safety of direct oral anticoagulants
(DOACs) in patients with a body mass index> 40 kg/m 2 or a weight> 120 kg, the use of …

Comparative Effectiveness and Safety of Direct Oral Anticoagulants in Obese Patients with Atrial Fibrillation

B Alexandros, M Amgad, A Mazur… - … Drugs and Therapy, 2021 - search.proquest.com
Background Unlike warfarin direct oral anticoagulants (DOACs) are administered in fixed
doses, which raises concerns of its effectiveness on larger patients. Data from randomized …

Direct oral anticoagulants versus warfarin in morbidly obese patients with nonvalvular atrial fibrillation: a systematic review and meta-analysis

M Mhanna, A Beran, A Al-Abdouh… - American Journal of …, 2021 - journals.lww.com
Background: Direct oral anticoagulants (DOACs) have been increasingly preferred over
warfarin; however, The International Society of Thrombosis and Hemostasis recommended …

Effectiveness and safety of apixaban vs. warfarin in venous thromboembolism patients with obesity and morbid obesity

A Cohen, J Sah, T Lee, L Rosenblatt… - Journal of Clinical …, 2021 - mdpi.com
This study integrated 5 United States healthcare claims databases to evaluate the risk of
recurrent venous thromboembolism (VTE) and major bleeding (MB) among VTE patients …

Factor Xa inhibitors versus vitamin K antagonist in morbidly obese patients with venous thromboembolism: a systematic review and meta-analysis

DY Park, S An, AW Arif, MK Sana, A Vij - BMC Cardiovascular Disorders, 2023 - Springer
Introduction Guidelines have endorsed non-vitamin K antagonist oral anticoagulants
(NOACs), consisting of factor Xa inhibitors (xabans) and direct thrombin inhibitors, as the first …

Direct oral anticoagulant concentrations in obese and high body weight patients: a cohort study

AC Martin, W Thomas, Z Mahir… - Thrombosis and …, 2021 - thieme-connect.com
Background Direct oral anticoagulants (DOACs) are prescribed for atrial fibrillation (AF) and
venous thromboembolism (VTE) and both occur more frequently in obese patients …

Management of venous thromboembolism in morbidly obese patients: A 10-year review

B Wee, B Lui, J Lai, Z Khattak, A Kwok… - Journal of Thrombosis …, 2023 - Springer
Obesity is a known risk factor for venous thromboembolism (VTE) and poses a unique set of
challenges in anticoagulation management. We report a 10-year experience of VTE …