SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity

SSF Nielsen, LK Vibholm, I Monrad, R Olesen… - …, 2021 - thelancet.com
Abstract Background The SARS-CoV-2 pandemic currently prevails worldwide. To
understand the immunological signature of SARS-CoV-2 infections and aid the search and …

Relative ratios of human seasonal coronavirus antibodies predict the efficiency of cross-neutralization of SARS-CoV-2 spike binding to ACE2

Y Galipeau, V Siragam, G Laroche, E Marion… - …, 2021 - thelancet.com
Background Antibodies raised against human seasonal coronaviruses (sCoVs), which are
responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This …

Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals

F Zhang, R Gan, Z Zhen, X Hu, X Li, F Zhou… - Signal transduction and …, 2020 - nature.com
The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has
affected more than eight million people. There is an urgent need to investigate how the …

SARS‐CoV‐2‐specific humoral and cellular immunity persists through 9 months irrespective of COVID‐19 severity at hospitalisation

JT Sandberg, R Varnaitė, W Christ… - Clinical & …, 2021 - Wiley Online Library
Objectives Humoral and cellular immunity to SARS‐CoV‐2 following COVID‐19 will likely
contribute to protection from reinfection or severe disease. It is therefore important to …

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

K Röltgen, AE Powell, OF Wirz, BA Stevens… - Science …, 2020 - science.org
SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding
domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can …

Different innate and adaptive immune responses to SARS-CoV-2 infection of asymptomatic, mild, and severe cases

R Carsetti, S Zaffina, E Piano Mortari, S Terreri… - Frontiers in …, 2020 - frontiersin.org
SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum
of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to …

Competitive SARS-CoV-2 serology reveals most antibodies targeting the spike receptor-binding domain compete for ACE2 binding

JR Byrnes, XX Zhou, I Lui, SK Elledge, JE Glasgow… - MSphere, 2020 - Am Soc Microbiol
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread
around the world, there is an urgent need for new assay formats to characterize the humoral …

[HTML][HTML] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity

CR Moderbacher, SI Ramirez, JM Dan, A Grifoni… - Cell, 2020 - cell.com
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …

Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2

L Ni, F Ye, ML Chen, Y Feng, YQ Deng, H Zhao, P Wei… - MedRxiv, 2020 - medrxiv.org
The WHO has declared SARS-CoV-2 outbreak a public health emergency of international
concern. However, to date, there was hardly any study in characterizing the immune …

Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6–8 months after the infection

N Sherina, A Piralla, L Du, H Wan, M Kumagai-Braesch… - Med, 2021 - cell.com
Background Monitoring the adaptive immune responses during the natural course of severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection provides useful …