Liver fatty acid-binding protein and obesity

BP Atshaves, GG Martin, HA Hostetler… - The Journal of nutritional …, 2010 - Elsevier
While low levels of unesterified long chain fatty acids (LCFAs) are normal metabolic
intermediates of dietary and endogenous fat, LCFAs are also potent regulators of key …

Hepatic phenotype of liver fatty acid binding protein gene-ablated mice

GG Martin, BP Atshaves, H Huang… - American Journal …, 2009 - journals.physiology.org
Although the function of liver fatty acid binding protein in hepatic fatty acid metabolism has
been extensively studied, its potential role in hepatic cholesterol homeostasis is less clear …

[PDF][PDF] Protection against Western diet–induced obesity and hepatic steatosis in liver fatty acid–binding protein knockout mice

EP Newberry, Y Xie, SM Kennedy, J Luo… - …, 2006 - Wiley Online Library
Liver fatty acid–binding protein (L‐Fabp) regulates murine hepatic fatty acid trafficking in
response to fasting. In this study, we show that L‐Fabp−/− mice fed a high‐fat Western diet …

[HTML][HTML] Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene

EP Newberry, Y Xie, S Kennedy, X Han… - Journal of Biological …, 2003 - ASBMB
Liver fatty acid-binding protein (L-Fabp) is an abundant cytosolic lipid-binding protein with
broad substrate specificity, expressed in mammalian enterocytes and hepatocytes. We have …

Diet-induced obesity and hepatic steatosis in L-Fabp−/− mice is abrogated with SF, but not PUFA, feeding and attenuated after cholesterol supplementation

EP Newberry, SM Kennedy, Y Xie… - American Journal …, 2008 - journals.physiology.org
Liver fatty acid (FA)-binding protein (L-Fabp), a cytoplasmic protein expressed in liver and
small intestine, regulates FA trafficking in vitro and plays an important role in diet-induced …

Liver fatty acid binding protein gene ablation potentiates hepatic cholesterol accumulation in cholesterol-fed female mice

GG Martin, BP Atshaves, AL McIntosh… - American Journal …, 2006 - journals.physiology.org
Although liver fatty acid binding protein (L-FABP) is postulated to influence cholesterol
homeostasis, the physiological significance of this hypothesis remains to be resolved. This …

[HTML][HTML] Tissue-specific functions in the fatty acid-binding protein family

J Storch, AE Thumser - Journal of Biological Chemistry, 2010 - ASBMB
The intracellular fatty acid-binding proteins (FABPs) are abundantly expressed in almost all
tissues. They exhibit high affinity binding of a single long-chain fatty acid, with the exception …

Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis

WS Lagakos, AM Gajda, L Agellon… - American Journal …, 2011 - journals.physiology.org
It has long been known that mammalian enterocytes coexpress two members of the fatty
acid-binding protein (FABP) family, the intestinal FABP (IFABP) and the liver FABP (LFABP) …

Fatty acid-binding proteins: functional understanding and diagnostic implications

H Xu, A Diolintzi, J Storch - Current Opinion in Clinical Nutrition & …, 2019 - journals.lww.com
The nine fatty acid-binding members of the FABP family have unique tissue-specific
functions and important secondary effects on tissues in which they are not expressed. For …

The Multifunctional Family of Mammalian Fatty Acid–Binding Proteins

J Storch, B Corsico - Annual review of nutrition, 2023 - annualreviews.org
Fatty acid–binding proteins (FABPs) are small lipid-binding proteins abundantly expressed
in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have …