[HTML][HTML] A novel microglia-specific transcriptional signature correlates with behavioral deficits in neuropsychiatric lupus
HM Makinde, DR Winter, D Procissi, EV Mike… - Frontiers in …, 2020 - frontiersin.org
Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half
of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that …
of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that …
Inhibitor of NF‐κB kinase subunit ε contributes to neuropsychiatric manifestations in lupus‐prone mice through microglial activation
K Karino, M Kono, S Takeyama, Y Kudo… - Arthritis & …, 2023 - Wiley Online Library
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease
characterized by multiorgan dysfunction. Neuropsychiatric SLE (NPSLE) occurs in 30–40 …
characterized by multiorgan dysfunction. Neuropsychiatric SLE (NPSLE) occurs in 30–40 …
Microglia activation in the presence of intact blood–brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric …
Introduction Inflammatory mediators are detected in the cerebrospinal fluid of systemic lupus
erythematosus patients with central nervous system involvement (NPSLE), yet the …
erythematosus patients with central nervous system involvement (NPSLE), yet the …
[HTML][HTML] Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer's disease not evident in mouse models
BA Friedman, K Srinivasan, G Ayalon, WJ Meilandt… - Cell reports, 2018 - cell.com
Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …
of their possible activation states is not well understood. We derived co-regulated gene …
[HTML][HTML] Neuron–microglia interactions in mental health disorders:“for better, and for worse”
ES Wohleb - Frontiers in immunology, 2016 - frontiersin.org
Persistent cognitive and behavioral symptoms that characterize many mental health
disorders arise from impaired neuroplasticity in several key corticolimbic brain regions …
disorders arise from impaired neuroplasticity in several key corticolimbic brain regions …
[HTML][HTML] Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice
AD Stock, J Wen, J Doerner, LC Herlitz… - Journal of …, 2015 - Springer
Background Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease
marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys …
marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys …
Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases
Microglia are resident macrophages of the brain parenchyma and play an essential role in
various aspects of brain development, plasticity, and homeostasis. With recent advances in …
various aspects of brain development, plasticity, and homeostasis. With recent advances in …
The potential pathogenetic link between peripheral immune activation and the central innate immune response in neuropsychiatric systemic lupus erythematosus
M Tomita, RL Khan, BH Blehm, TJ Santoro - Medical hypotheses, 2004 - Elsevier
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology.
Neuropsychiatric disturbances unexplained by drugs or by other untoward manifestations of …
Neuropsychiatric disturbances unexplained by drugs or by other untoward manifestations of …
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …
[HTML][HTML] Microglia transcriptome changes in a model of depressive behavior after immune challenge
D Gonzalez-Pena, SE Nixon, JC O'Connor… - PloS one, 2016 - journals.plos.org
Depression symptoms following immune response to a challenge have been reported after
the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia …
the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia …