Background/Objective: Currently, 30% of the USA population has non-alcoholic fatty liver
disease (NAFLD), a condition that is increasing in parallel with the global obesity epidemic …

In contrast to many other medical conditions, obesity has increased drastically in prevalence
throughout the 20 th Century. The lack of success in the control of obesity may be traced to …

Genome-wide association studies have found that a high proportion of variants that correlate
with elevated body mass index are expressed in the central nervous system, signifying that …

Rodent models in which monogenic alterations cause obesity in the absence of
environmental changes have confirmed earlier inferences regarding the biologic/genetic …

Obesity is a major public health concern in the 2 1st century. Approximately one-third of US
adults are obese, with the prevalence of obesity and related conditions like …

There is a high demand for effective pharmacotherapy against obesity as its prevalence
increases worldwide. Rodent models have advanced our knowledge of energy homeostasis …

Highly inbred C57BL/6 mice show wide variation in their degree of insulin resistance in
response to diet-induced obesity even though they are almost genetically identical. Here we …

The epidemic of obesity has been affecting individuals globally, with roughly 650 million
adults obese in 2016 (WHO, 2021). According to the Centers for Disease Control and …

High fat feeding in rodents generally leads to obesity and insulin resistance whereas in
humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …