Lessons in obesity from transgenic animals

JRS Arch - Journal of endocrinological investigation, 2002 - Springer
Many genetic manipulations have created models of obesity, leanness or resistance to
dietary obesity in mice, often providing insights into molecular mechanisms that affect …

Withdrawing from obesogenic diets: benefits and barriers in the short-and long-term in rodent models

BP Casagrande, D Estadella - American Journal of …, 2020 - journals.physiology.org
There is accumulating evidence of dietary impact on several metabolic parameters.
Unhealthy diets are estimated to be responsible for about 20% of the deaths worldwide. The …

Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse

M González-Granillo, LA Helguero, E Alves… - Biology of sex …, 2019 - Springer
The response to overfeeding is sex dependent, and metabolic syndrome is more likely
associated to obesity in men or postmenopausal women than in young fertile women. We …

Sex differences in metabolic recuperation after weight loss in high fat diet-induced obese mice

S Guerra-Cantera, LM Frago… - Frontiers in …, 2021 - frontiersin.org
Dietary intervention is a common tactic employed to curtail the current obesity epidemic.
Changes in nutritional status alter metabolic hormones such as insulin or leptin, as well as …

Obesity—On or Off?

F Karpe, CM Lindgren - New England Journal of Medicine, 2016 - Mass Medical Soc
Obesity — On or Off? | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

[图书][B] Obesity: genomics and postgenomics

K Clément, TIA Sorensen - 2007 - books.google.com
This book comprehensively accounts the current understanding of genetic mechanisms of
obesity by analyzing obesity phenotypes and genotypes and, gene polymorphisms and …

The genetics of obesity

J Naggert, T Harris, M North - Current opinion in genetics & development, 1997 - Elsevier
Despite the influence of obesity in predisposing to many diseases, and evidence for high
heritability, efforts to identify human genes with major effects on bodyweight have not yet …

Lipidomic analysis of serum from high fat diet induced obese mice

K Eisinger, G Liebisch, G Schmitz, C Aslanidis… - International journal of …, 2014 - mdpi.com
Lipid metabolites regulate fatty acid and glucose homeostasis. The intention of the current
study is to identify circulating lipid species, which are altered in rodent obesity and strongly …

Energy expenditure in obese and weight cycled mice (640.5)

D Chusyd, M Johnson, D Smith, Y Yang… - The FASEB …, 2014 - Wiley Online Library
Male C57BL/6J mice were used to investigate diet‐induced obesity with subsequent weight
loss and regain (weight cycling–WC; n= 9). Mice were ad libitum fed a high fat diet (45% cal …

Combining a low fat diet with exercise reverses diet-induced obesity and improves glucose homeostasis in C57BL/6J mice

H Andersen - 2015 - bora.uib.no
Background: The prevalence of obesity and obesity-related disorders, including type 2
diabetes and non-alcohol fatty liver disease is alarmingly high. These conditions can mostly …