Lgr5+ intestinal stem cells (ISCs) reside within specialized niches at the crypt base and
harbor self-renewal and differentiation capacities. ISCs in the crypt base are sustained by …

Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via
promoting a healthy gut barrier. Within the stem cell niche, gut microbiota linking the …

Intestinal epithelium undergoes rapid cellular turnover, relying on the local niche, to support
intestinal stem cells (ISCs) function and self‐renewal. Research into the association …

Diet can impact on gut health and disease by modulating intestinal stem cells (ISCs).
However, it is largely unknown if and how the ISC niche responds to diet and influences ISC …

The gut microbiota fundamentally regulates intestinal homeostasis and disease partially
through mechanisms that involve modulation of regulatory T cells (Tregs), yet how the …

Microorganisms that colonize the gastrointestinal tract, collectively known as the gut
microbiota, are known to produce small molecules and metabolites that significantly …

In the small intestine, a niche of accessory cell types supports the generation of mature
epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how …

Gut microbes play important roles in host physiology; however, the mechanisms underlying
their impact remain poorly characterized. Here, we demonstrate that microbes not only …

The high turnover and regenerative capacity of the adult intestine relies on resident stem
cells located at the bottom of the crypt. The enteric nervous system consists of an abundant …

The mammalian intestinal epithelial stem cell (IESC) niche is comprised of diverse epithelial,
immune, and stromal cells, which together respond to environmental changes within the …