Kaempferol‐induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK‐MAPK

TTT Nguyen, E Tran, CK Ong, SK Lee… - Journal of cellular …, 2003 - Wiley Online Library
A vast variety of naturally occurring substances have been shown to protect against
experimental carcinogenesis and an increasing amount of evidence suggests that …

Kaempferol: A potential agent in the prevention of colorectal cancer

HR Nejabati, L Roshangar - Physiological reports, 2022 - Wiley Online Library
Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and
mortality rate and its incidence is considerably increasing annually due to the change in the …

[HTML][HTML] Role of induced programmed cell death in the chemopreventive potential of apigenin

JY Jang, B Sung, ND Kim - International Journal of Molecular Sciences, 2022 - mdpi.com
The flavonoid apigenin (4′, 5, 7-trihydroxyflavone), which is one of the most widely
distributed phytochemicals in the plant kingdom, is one of the most thoroughly investigated …

The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways

AA Alshatwi, E Ramesh, VS Periasamy… - Fundamental & …, 2013 - Wiley Online Library
Hesperetin, a flavonoid from citrus fruits, has several bioactivities such as anti‐inflammatory,
antihypertensive, antiatherogenic effects. However, studies elucidating the role and the …

[HTML][HTML] Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis

S Srivastava, RR Somasagara, M Hegde, M Nishana… - Scientific reports, 2016 - nature.com
Naturally occurring compounds are considered as attractive candidates for cancer treatment
and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly …

Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis

H Zhao, L Han, Y Jian, Y Ma, W Yan… - OncoTargets and …, 2018 - Taylor & Francis
Background Resveratrol is known as a natural phytoalexin found in grapes and wine, which
has significant antitumor activity under in vitro and in vivo conditions. In recent years, great …

Quercetin‐induced apoptotic cascade in cancer cells: Antioxidant versus estrogen receptor α‐dependent mechanisms

P Galluzzo, C Martini, P Bulzomi… - Molecular nutrition & …, 2009 - Wiley Online Library
The flavonol quercetin, especially abundant in apple, wine, and onions, is reported to have
anti‐proliferative effects in many cancer cell lines. Antioxidant or pro‐oxidant activities and …

Genistein potentiates Centchroman induced antineoplasticity in breast cancer via PI3K/Akt deactivation and ROS dependent induction of apoptosis

S Kaushik, H Shyam, S Agarwal, R Sharma, TC Nag… - Life sciences, 2019 - Elsevier
Aims Recently, strategies of cancer treatment using combination of agents with distinct
molecular mechanism (s) of action are considered more promising due to its high efficacy …

Naringenin induces intrinsic and extrinsic apoptotic signaling pathways in cancer cells: A systematic review and meta-analysis of in vitro and in vivo data

F Faramarzi, M Alimohammadi, A Rahimi… - Nutrition Research, 2022 - Elsevier
Various reports show the beneficial effect of naringenin on the development of cancer. We
hypothesized that naringenin suppresses cancer cells by activating intrinsic and extrinsic …

[HTML][HTML] Kaempferol: A key emphasis to its anticancer potential

M Imran, B Salehi, J Sharifi-Rad, T Aslam Gondal… - Molecules, 2019 - mdpi.com
A marked decrease in human cancers, including breast cancer, bone cancer, and cervical
cancer, has been linked to the consumption of vegetable and fruit, and the corresponding …