As solid tumours rely upon the bloodstream to deliver nutrients necessary for growth, it
follows that interference with that supply may compromise tumour growth. Indeed, this …

An extensive biomedical literature attests to the controversy regarding the significance of
coagulation activation in cancer. It has been known for over a century that thromboembolism …

It must be admitted that we have little sound information about the pathogenesis of either the
thrombotic or the bleeding syndrome that may occur with malignant tumors. For many years …

Routine blood coagulation tests were performed on 431 consecutive patients enrolled in a
study of the role of anticoagulation in cancer treatment (VA Cooperative Study# 75). Two …

Fibrinopeptide A (FPA) levels have been followed sequentially in a three‐year study of 50
patients with advanced carcinoma. Evidence for activation of blood coagulation was found in …

Coagulation tests including platelet count, factor V assay, fibrinogen, fibrin split products,
and serial thrombin time were performed on 51 patients with cancer. Elevated fibrin split …

A relation between hypercoagulability and cancer has been recognized for more than 125
years. Trousseau, 1 lecturing on phlegmasia alba dolens in 1872, noted that deep-vein …

Although Trousseau1 was the earliest observer who noted the association between cancer
and thrombosis, it was Billroth2 who first described the presence of tumor cells within a …

Blood coagulation test results were collected prospectively in patients with previously
untreated, advanced lung or colon cancer who entered into a clinical trial. In patients with …

The relationship between increased clotting and malignancy is well recognized, though the
bidirectional development of this association is often overlooked. In the challenging cancer …