The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota

Y Zhang, A Saint Fleur, H Feng - Gut Microbes, 2022 - Taylor & Francis
Clostridioides difficile is the most prevalent pathogen of nosocomial diarrhea. In the United
States, over 450,000 cases of C. difficile infection (CDI), responsible for more than 29,000 …

Microbiota-Based Live Biotherapeutic Products for Clostridioides Difficile Infection- The Devil is in the Details

L Monday, G Tillotson, T Chopra - Infection and Drug Resistance, 2024 - Taylor & Francis
Clostridioides difficile infection (CDI) remains a significant contributor to healthcare costs
and morbidity due to high rates of recurrence. Currently, available antibiotic treatment …

Clostridioides difficile infection: microbe-microbe interactions and live biotherapeutics

R Wang - Frontiers in Microbiology, 2023 - frontiersin.org
Clostridioides difficile is a gram-positive, spore-forming, obligate anaerobe that infects the
colon. C. difficile is estimated to cause nearly half a million cases in the United States …

Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies

P Berry, S Khanna - BioDrugs, 2023 - Springer
Clostridioides difficile is one of the most important causes of healthcare-associated diarrhea.
The high incidence and recurrence rates of C. difficile infection, as well as its associated …

The potential for emerging therapeutic options for Clostridium difficile infection

H Mathur, MC Rea, PD Cotter, RP Ross, C Hill - Gut microbes, 2014 - Taylor & Francis
Clostridium difficile is mainly a nosocomial pathogen and is a significant cause of antibiotic-
associated diarrhea. It is also implicated in the majority of cases of pseudomembranous …

[HTML][HTML] Frontiers in antibiotic alternatives for Clostridioides difficile infection

M Phanchana, P Harnvoravongchai… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Clostridioides difficile (C. difficile) is a gram-positive, anaerobic spore-forming bacterium and
a major cause of antibiotic-associated diarrhea. Humans are naturally resistant to C. difficile …

1953. VE303, a Rationally Designed Bacterial Consortium for Prevention of Recurrent Clostridioides difficile (C. Difficile) infection (rCDI), Stably Restores the Gut …

D Bobilev, S Bhattarai, R Menon, B Klein… - Open Forum …, 2019 - academic.oup.com
Background Gut microbiota alterations and resulting changes in metabolites involved in
colonization resistance and host responses, including bile acids (BA) and short-chain fatty …

Probiotics: insights and new opportunities for Clostridioides difficile intervention

R Pal, AIM Athamneh, R Deshpande… - Critical reviews in …, 2023 - Taylor & Francis
Clostridioides difficile infection (CDI) is a life-threatening disease caused by the Gram-
positive, opportunistic intestinal pathogen C. difficile. Despite the availability of antimicrobial …

[HTML][HTML] Clostridioides difficile infection: Landscape and microbiome therapeutics

BJ Gawey, S Khanna - Gastroenterology & Hepatology, 2023 - ncbi.nlm.nih.gov
Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and
is common in the community. Both younger individuals who may be healthy otherwise and …

Treating Clostridioides difficile: could microbiota-based live biotherapeutic products provide the answer?

S Nagarakanti, R Orenstein - Infection and Drug Resistance, 2023 - Taylor & Francis
Clostridioides difficile infection (CDI) is a pressing health care issue due to the limited
effectiveness of current treatments and high recurrence rates. Current available antibiotic …