While a definitive understanding of schizophrenia etiology is far from current reality, an
increasing body of evidence implicates perturbations in early development that alter the …

Background Schizophrenia is a severe mental illness afflicting young adults just as they
approach their full potential, often resulting in a lifetime of severe disability. While many …

Genetic association studies of psychiatric disorders have provided unprecedented insight
into disease risk profiles with high confidence. Yet, the next research challenge is how to …

Schizophrenia is routinely referred to as a neurodevelopmental disorder, but the role of
brain development in a disorder typically diagnosed during early adult life is enigmatic. The …

Schizophrenia is a chronic mental illness with a substantial genetic component. To unfold
the complex etiology of schizophrenia, it is important to understand the interplay between …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

Recent advances in our understanding of the genetic architecture of schizophrenia have
shed light on the schizophrenia etiology. While common variation is one of the major genetic …

Large‐scale consortia including the Psychiatric Genomics Consortium, the Common Minds
Consortium, BrainSeq and PsychENCODE, and many other studies taken together provide …

Highlights•Schizophrenia is a neuropsychiatric disorder hypothesized to involve
neurodevelopmental changes in gene regulation.•Epigenetic modifications play a …

Non-coding variants increase risk of neuropsychiatric disease. However, our understanding
of the cell-type specific role of the non-coding genome in disease is incomplete. We …