DNA strand breaks, acute phase response and inflammation following pulmonary exposure by instillation to the diesel exhaust particle NIST1650b in mice

ZO Kyjovska, NR Jacobsen, AT Saber… - …, 2015 - academic.oup.com
We investigated the inflammatory response, acute phase response and genotoxic effect of
diesel exhaust particles (DEPs, NIST1650b) following a single intratracheal instillation …

Inflammatory and genotoxic effects of diesel particles in vitro and in vivo

M Dybdahl, L Risom, J Bornholdt, H Autrup… - … /Genetic Toxicology and …, 2004 - Elsevier
Recent studies have identified an indirect genotoxicity pathway involving inflammation as
one of the mechanisms underlying the carcinogenic effects of air pollution/diesel exhaust …

DNA damage in lung after oral exposure to diesel exhaust particles in Big Blue® rats

AK Müller, EO Farombi, P Møller, HN Autrup… - Mutation Research …, 2004 - Elsevier
Several chemical mutagens and carcinogens, including polycyclic aromatic hydrocarbons
(PAHs) and nitrated PAHs, are adsorbed to the surface of diesel exhaust particles (DEP) …

Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties

KM Bendtsen, L Gren, VB Malmborg, PC Shukla… - Particle and Fibre …, 2020 - Springer
Background Diesel exhaust is carcinogenic and exposure to diesel particles cause health
effects. We investigated the toxicity of diesel exhaust particles designed to have varying …

Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

K Jantzen, M Roursgaard, C Desler, S Loft… - …, 2012 - academic.oup.com
Studies in mono-culture of cells have shown that diesel exhaust particles (DEPs) increase
the production of reactive oxygen species (ROS) and oxidative stress–related damage to …

Micronucleus induction and phagocytosis in mammalian cells treated with diesel emission particles

G Zu-Wei, Z Bao-Zhen, B Nath, W Wen-Zong… - Mutation Research …, 1992 - Elsevier
Micronucleus induction and phagocytosis in V79 and CHO cells treated with diesel emission
particles (DEP) were studied. After separation of the sample into supernatant and sediment …

Mutagenicity of diesel exhaust particles mediated by cell–particle interaction in mammalian cells

L Bao, S Chen, L Wu, TK Hei, Y Wu, Z Yu, A Xu - Toxicology, 2007 - Elsevier
Diesel exhaust particle (DEP) has been identified as a class 2A human carcinogen and
closely related to the increased incidence of respiratory allergy, cardiopulmonary morbidity …

DNA damage in rats after a single oral exposure to diesel exhaust particles

PH Danielsen, L Risom, H Wallin, H Autrup… - Mutation Research …, 2008 - Elsevier
The gastrointestinal route of exposure to particulate matter is important because particles
are ingested via contaminated foods and inhaled particles are swallowed when removed …

Can toxicogenomics provide information on the bioreactivity of diesel exhaust particles?

LJ Reynolds, RJ Richards - Toxicology, 2001 - Elsevier
Epidemiologists have linked increased cardio-respiratory hospital admissions, morbidity and
mortality rates and increases in particulate matter with an aerodynamic diameter less than …

Pulmonary inflammation and DNA adducts in rats inhaling diesel exhaust or carbon black

RK Wolff, JA Bond, RF Henderson… - Inhalation …, 1990 - Taylor & Francis
Inhaled diesel exhaust has been shown to be carcinogenic to rats. Two mechanisms have
been suggested: a genotoxic effect of organic compounds associated with the diesel soot …