Antibiotic resistance is one of the greatest current threats to human health, and without
significant action we face the chilling prospect of a world without effective antibiotics …

The traditional definition of natural antibodies (NAbs) states that these antibodies are
present prior to the body encountering cognate antigen, providing a first line of defense …

Antimicrobial resistance (AMR) is a major health concern worldwide. A better understanding
of the underlying molecular mechanisms is needed. Advances in whole genome …

Antimicrobial resistance (AMR) in bacteria is a major threat to public health; one of the key
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …

Antibodies can be used for the prevention and treatment of bacterial infections in animal
models of disease. Current antibody technology allows the generation of high affinity …

First, for rare or emerging diseases, such as Ebola, pandemic influenza or MERS-CoV,
demonstrating proof of concept in clinical trials is difficult. The small number of patients, the …

Overuse of antibiotics in humans and livestock has led to the rapid evolution of bacteria that
are resistant to multiple drugs such that even vancomycin, the drug of last resort, is no longer …

Since the development of antibody-production techniques, a number of immunoglobulins
have been developed on a large scale using conventional methods. Hybridoma technology …

Natural antibodies are produced at tightly regulated levels in the complete absence of
external antigenic stimulation. They provide immediate, early and broad protection against …