[HTML][HTML] c‐jun N‐terminal kinase is involved in AUUUA‐mediated interleukin‐3 mRNA turnover in mast cells
XF Ming, M Kaiser, C Moroni - The EMBO journal, 1998 - embopress.org
Whereas signalling pathways involved in transcriptional control have been studied
extensively, the pathways regulating mRNA turnover remain poorly understood. We are …
extensively, the pathways regulating mRNA turnover remain poorly understood. We are …
Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay.
G Stoecklin, S Hahn, C Moroni - Journal of Biological Chemistry, 1994 - ASBMB
In mast cells, expression of interleukin-3 (IL-3) is induced following IgE-receptor activation
via calcium-dependent mRNA stabilization. We performed a mutational analysis of the 8 …
via calcium-dependent mRNA stabilization. We performed a mutational analysis of the 8 …
[HTML][HTML] The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted …
R Winzen, M Kracht, B Ritter, A Wilhelm… - The EMBO …, 1999 - embopress.org
Stabilization of mRNAs contributes to the strong and rapid induction of genes in the
inflammatory response. The signaling mechanisms involved were investigated using a …
inflammatory response. The signaling mechanisms involved were investigated using a …
Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and-independent mechanisms
S Wang, J Zhang, Y Zhang, S Kern… - Journal of Leucocyte …, 2008 - academic.oup.com
Regulation of mRNA stability by p38 MAPK has been linked to adenosine-uridine-rich
elements (AURE) within the 3′-untranslated region (3′ UTR) of mRNA. Using microarrays …
elements (AURE) within the 3′-untranslated region (3′ UTR) of mRNA. Using microarrays …
[HTML][HTML] MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
A Neininger, D Kontoyiannis, A Kotlyarov… - Journal of Biological …, 2002 - ASBMB
We demonstrate that lipopolysaccharide-induced tumor necrosis factor (TNF) biosynthesis
becomes independent of MAPKAP kinase 2 (MK2) when the AU-rich element (ARE) of the …
becomes independent of MAPKAP kinase 2 (MK2) when the AU-rich element (ARE) of the …
Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase
XF Ming, G Stoecklin, M Lu, R Looser… - Molecular and cellular …, 2001 - Taylor & Francis
AU-rich elements (ARE) present in the 3′ untranslated regions of many cytokines and
immediate-early genes are responsible for targeting the transcripts for rapid decay. We …
immediate-early genes are responsible for targeting the transcripts for rapid decay. We …
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
CY Chen, R Gherzi, JS Andersen… - Genes & …, 2000 - genesdev.cshlp.org
Regulated mRNA turnover is a highly important process, but its mechanism is poorly
understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK …
understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK …
Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1
S Paschoud, AM Dogar, C Kuntz… - … and cellular biology, 2006 - Am Soc Microbiol
Interleukin-6 mRNA is unstable and degraded with a half-life of 30 min. Instability
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …
The role of mammalian MAPK signaling in regulation of cytokine mRNA stability and translation
Extracellular-regulated kinases and p38 mitogen-activated protein kinases are activated in
innate (and adaptive) immunity and signal via different routes to alter the stability and …
innate (and adaptive) immunity and signal via different routes to alter the stability and …
Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine-or stress-activated signal …
H Holtmann, R Winzen, P Holland… - … and cellular biology, 1999 - Taylor & Francis
A hallmark of inflammation is the burst-like formation of certain proteins, initiated by cellular
stress and proinflammatory cytokines like interleukin 1 (IL-1) and tumor necrosis factor …
stress and proinflammatory cytokines like interleukin 1 (IL-1) and tumor necrosis factor …