The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of
gene regulation to adapt to stressors it encounters in the human host, such as oxidative …

Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …

In response to the host environment, the human pathogen Cryptococcus neoformans must
rapidly reprogram its translatome from one which promotes growth to one which is …

Cryptococcus neoformans is a human fungal pathogen that survives exposure to stresses
during growth in the human host, including oxidative and nitrosative stress, high …

The ability of the fungal pathogen Cryptococcus neoformans to evade the mammalian innate
immune response and cause disease is partially due to its ability to respond to and survive …

Nitrogen availability is vital for the growth and survival of Cryptococcus neoformans in the
natural environment. Two major ecological reservoirs were previously described for C …

Stress management is an adaptive advantage for survival in adverse environments.
Pathogens face this challenge during host colonization, requiring an appropriate stress …

Proper regulation of metabolism is essential to maximizing fitness of organisms in their
chosen environmental niche. Nitrogen metabolite repression is an example of a regulatory …

The ability to sense and adapt to a hostile host environment is a crucial element for virulence
of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are …

Nitrogen limitation was previously shown to be an important regulator of several genes
associated with virulence in Cryptococcus neoformans. Among the most highly expressed …