Antibodies against foreign antigens are a critical component of the overall immune response
and can facilitate pathogen clearance during a primary infection and also protect against …

The B cell receptor (BCR) triggers a variety of biological responses that differ depending
upon the properties of the antigen. A panel of M13 phage-displayed peptide ligands with …

B-1 cells differ from conventional B-2 cells both phenotypically and functionally. Two
seemingly mutually exclusive hypotheses have been proposed to explain the origin of B-1 …

Constitutive signal transduction by B cell antigen-receptors and/or their surrogates appears
to be critical for progression through multiple developmental checkpoints and for survival of …

A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and
functions that are distinct from those of conventional B cells exist in mice. It contributes the …

There is growing interest in the fundamental roles that B cells may play in regulating immune
responses. Emerging animal studies point to an important contribution of B cell effector …

B cells act as immune effectors, primarily through antigen-specific clonal expansion and
plasma-cell differentiation. B1 (CD5+) B cells and marginal zone B cells dominate T-cell …

Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways
have been described in extraordinary molecular detail, mainly from studies of B cell …

B lymphocytes and their differentiated daughters are charged with responding to the myriad
pathogens in our environment and production of protective antibodies. A sample of the …

Highlights•Unique developmental paths generate self-reactive B-1 constraint in BCR
responses.•Extensive repertoire shaping of B-1 cells for months after birth.•Accumulating …