The realization that the meticulous organization of cellular organelles is not required for the
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …

Vesicle trafficking from the endoplasmic reticulum (ER) is a vital cellular process in all
eukaryotes responsible for moving secretory cargoes from the ER to the Golgi apparatus. To …

The first membrane trafficking step in the biosynthetic secretory pathway, the export of
proteins and lipids from the endoplasmic reticulum (ER), is mediated by COPII-coated …

Transport in the ER–Golgi shuttle is performed by COPII in the anterograde and by COPI in
the retrograde direction. How these transport steps are regulated and which mechanisms act …

The intermediate compartment residing between the endoplasmic reticulum (ER) and the
Golgi is now recognized to be a dynamic structure that captures cargo released from the ER …

Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the
initial step in protein secretion. COPII‐coated vesicles mediate the export of newly …

Transport through the secretory pathway begins with COPII regulation of ER export. Driven
by the Sar1 GTPase cycle, cytosolic COPII proteins exchange on and off the membrane at …

First discovered by genetic analysis of yeast secretion mutants, the evolutionarily conserved
vesicular coat protein II (COPII) complex is responsible for membrane transport from the …

A full mechanistic understanding of how secretory cargo proteins are exported from the
endoplasmic reticulum for passage through the early secretory pathway is essential for us to …

Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …