Mutations in the human FOXP2 gene cause impaired speech development and linguistic
deficits, which have been best characterised in a large pedigree called the KE family. The …

Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties
in sequencing orofacial movements. FOXP2 is expressed in cortico-striatal and cortico …

Highlights•Mutations of the FOXP2 gene cause a severe speech and language
disorder.•Mice with Foxp2 disruptions have provided valuable insights into its …

Genetic studies have associated FOXP2 variation with speech and language disorders and
other neurodevelopmental disorders (NDDs) involving pathology of the cortex. In this brain …

The most well-described example of an inherited speech and language disorder is that
observed in the multigenerational KE family, caused by a heterozygous missense mutation …

Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …

Background Mutations in the gene encoding the transcription factor forkhead box P2
(FOXP2) result in brain developmental abnormalities, including reduced gray matter in both …

Heterozygous mutations of the Forkhead-box protein 2 (FOXP2) gene in humans cause
childhood apraxia of speech. Loss of Foxp2 in mice is known to affect striatal development …

Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-
described examples of monogenic speech and language disorders. Acquisition of proficient …

Rare disruptions of FOXP2 have been strongly implicated in deficits in language
development. Research over the past decade has suggested a role in the formation of …