Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder
E Sollis, SA Graham, A Vino, H Froehlich… - Human molecular …, 2016 - academic.oup.com
De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
Functional genetic analysis of mutations implicated in a human speech and language disorder
Mutations in the FOXP2 gene cause a severe communication disorder involving speech
deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments in …
deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments in …
[HTML][HTML] Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a
molecular window into the neurobiology of language. Individuals with FOXP2 mutations …
molecular window into the neurobiology of language. Individuals with FOXP2 mutations …
[HTML][HTML] A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution due to effects on aspects of speech …
have been positively selected during human evolution due to effects on aspects of speech …
Altered social behavior in mice carrying a cortical Foxp2 deletion
Genetic disruptions of the forkhead box transcription factor FOXP2 in humans cause an
autosomal-dominant speech and language disorder. While FOXP2 expression pattern are …
autosomal-dominant speech and language disorder. While FOXP2 expression pattern are …
Molecular networks of the FOXP2 transcription factor in the brain
The discovery of the FOXP2 transcription factor, and its implication in a rare severe human
speech and language disorder, has led to two decades of empirical studies focused on …
speech and language disorder, has led to two decades of empirical studies focused on …
Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language
In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as
the basis of an inherited speech and language disorder suffered by members of the family …
the basis of an inherited speech and language disorder suffered by members of the family …
An evolutionary perspective on FoxP2: strictly for the birds?
C Scharff, S Haesler - Current opinion in neurobiology, 2005 - Elsevier
FoxP2 mutations in humans are associated with a disorder that affects both the
comprehension of language and its production, speech. This discovery provided the first …
comprehension of language and its production, speech. This discovery provided the first …
Humanized Foxp2 specifically affects cortico-basal ganglia circuits
It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution and influence aspects of speech and …
have been positively selected during human evolution and influence aspects of speech and …
Birdsong decreases protein levels of FoxP2, a molecule required for human speech
Cognitive and motor deficits associated with language and speech are seen in humans
harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are …
harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are …