Foxp subfamily genes were recently recognized to be members of the Fox gene family. Foxp
subfamily members contain a zinc finger domain and a leucine zipper motif in addition to a …

Heterozygous mutations of the human FOXP2 gene are implicated in a severe speech and
language disorder. Aetiological mutations of murine Foxp2 yield abnormal synaptic plasticity …

FOXP2 is the major gene associated with severe, persistent, developmental speech and
language disorders. While studies in the original family in which a FOXP2 mutation was …

FOXP proteins form a subfamily of evolutionarily conserved transcription factors involved in
the development and functioning of several tissues, including the central nervous system. In …

Genetic perturbations of the transcription factor Forkhead Box P1 (FOXP1) are causative for
severe forms of autism spectrum disorder that are often comorbid with intellectual disability …

Cortico-basal ganglia circuits are critical for speech and language and are implicated in
autism spectrum disorder, in which language function can be severely affected. We …

FOXP2 is a forkhead transcription factor implicated in developmental verbal dyspraxia, a
human speech and language disorder. FOXP2 is expressed in complex patterns during …

The transcription factor FOXP2 has been linked to severe speech and language
impairments in humans. An analysis of the evolution of the FOXP2 gene has identified two …

Fundamental human traits, such as language and bipedalism, are associated with a range
of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is …

FOXP2 is a transcription factor containing a polyglutamine tract, a zinc-finger motif, and a
forkhead DNA-binding domain. The FOXP2 gene is located on 7q31. A missense mutation …