Human-specific transcriptional regulation of CNS development genes by FOXP2

G Konopka, JM Bomar, K Winden, G Coppola… - Nature, 2009 - nature.com
The signalling pathways controlling both the evolution and development of language in the
human brain remain unknown. So far, the transcription factor FOXP2 (forkhead box P2) is …

[HTML][HTML] FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways

P Devanna, J Middelbeek, SC Vernes - Frontiers in cellular …, 2014 - frontiersin.org
FOXP2 was the first gene shown to cause a Mendelian form of speech and language
disorder. Although developmentally expressed in many organs, loss of a single copy of …

Conservation and diversity of Foxp2 expression in muroid rodents: functional implications

P Campbell, RL Reep, ML Stoll… - Journal of …, 2009 - Wiley Online Library
FOXP2, the first gene causally linked to a human language disorder, is implicated in song
acquisition, production, and perception in oscine songbirds, the evolution of speech and …

[HTML][HTML] Transcription and beyond: delineating FOXG1 function in cortical development and disorders

PS Hou, DO HAilin, T Vogel… - Frontiers in cellular …, 2020 - frontiersin.org
Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant
roles in brain development, where alteration of this gene's expression significantly affects …

[HTML][HTML] Assessing the effects of common variation in the FOXP2 gene on human brain structure

M Hoogman, T Guadalupe, MP Zwiers… - Frontiers in human …, 2014 - frontiersin.org
The FOXP2 transcription factor is one of the most well-known genes to have been implicated
in developmental speech and language disorders. Rare mutations disrupting the function of …

Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain

RJ Ferland, TJ Cherry, PO Preware… - Journal of …, 2003 - Wiley Online Library
Foxp2 and Foxp1 are recently identified members of the Fox family of winged‐helix/forkhead
transcription factor genes. A recent study has found that mutations in human FOXP2 produce …

The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortex

T Hisaoka, Y Nakamura, E Senba, Y Morikawa - Neuroscience, 2010 - Elsevier
Foxp1 and Foxp2, which belong to the forkhead transcription factor family, are expressed in
the developing and adult mouse brain, including the striatum, thalamus, and cerebral cortex …

CNTNAP2 is a direct FoxP2 target in vitro and in vivo in zebra finches: complex regulation by age and activity

I Adam, E Mendoza, U Kobalz… - Genes, Brain and …, 2017 - Wiley Online Library
Mutations of FOXP2 are associated with altered brain structure, including the striatal part of
the basal ganglia, and cause a severe speech and language disorder. Songbirds serve as a …

Enhanced procedural learning of speech sound categories in a genetic variant of FOXP2

B Chandrasekaran, HG Yi, NJ Blanco… - Journal of …, 2015 - Soc Neuroscience
A mutation of the forkhead box protein P2 (FOXP2) gene is associated with severe deficits in
human speech and language acquisition. In rodents, the humanized form of FOXP2 …

[HTML][HTML] Duplications of FOXG1 in 14q12 are associated with developmental epilepsy, mental retardation, and severe speech impairment

N Brunetti-Pierri, AR Paciorkowski, R Ciccone… - European Journal of …, 2011 - nature.com
Genome-wide high-resolution array analysis is rapidly becoming a reliable method of
diagnostic investigation in individuals with mental retardation and congenital anomalies …