IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune …

EE McCandless, M Budde, JR Lees… - The Journal of …, 2009 - journals.aai.org
Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of
the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred …

CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis

LV Bagaeva, P Rao, JM Powers… - The Journal of …, 2006 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE) is a Tcell-mediated autoimmune
disease of the CNS that is widely used as an animal model of multiple sclerosis. In this …

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

E Mills Ko, JH Ma, F Guo, L Miers, E Lee… - Journal of …, 2014 - Springer
Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation,
demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells …

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

TL Sørensen, C Trebst, P Kivisäkk, KL Klaege… - Journal of …, 2002 - Elsevier
T-cell accumulation in the central nervous system (CNS) is considered crucial to the
pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the …

CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis

EE McCandless, Q Wang, BM Woerner… - The Journal of …, 2006 - journals.aai.org
The inflammatory response in the CNS begins with the movement of leukocytes across the
blood-brain barrier in a multistep process that requires cells to pass through a perivascular …

Lymphoid chemokines in chronic neuroinflammation

F Aloisi, S Columba-Cabezas, D Franciotta… - Journal of …, 2008 - Elsevier
Lymphoid chemokines play an essential role in the establishment and maintenance of
lymphoid tissue microarchitecture and have been implicated in the formation of tertiary (or …

CXCL10 (IFN-γ-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune …

BT Fife, KJ Kennedy, MC Paniagua… - The Journal of …, 2001 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating
disease of the CNS that serves as a model for multiple sclerosis. A critical event in the …

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

A Mildner, M Mack, H Schmidt, W Brück, M Djukic… - Brain, 2009 - academic.oup.com
The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in the
central nervous system. However, it remains unclear how the pathogenic response is …

The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro

C Raine - Journal of neuroimmunology, 2007 - jni-journal.com
There may be some problems with the data in the paper referenced above. I looked over the
technical aspects of the paper, having received notice from ScienceDirect that it was in …

Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease

BM Segal, L Bagaeva - US Patent 7,390,884, 2008 - Google Patents
Th1-mediated autoimmune disease of the central nervous system that is widely used as an
animal model of multiple sclerosis (MS). In this study it was demonstrate that CXCL13, a …