Monocyte-derived and tissue-resident macrophages are ontogenetically distinct
components of the innate immune system. Assessment of their respective functions in …

Immune damages on the peripheral myelin sheath under pro-inflammatory milieu result in
primary demyelination in inflammatory demyelinating neuropathy. Inflammatory cytokines …

Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute
encephalomyelitis followed by a chronic demyelinating disease with clinical and histological …

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) wherein T helper (Th) 17 cells are the major pathogenic players orchestrating …

Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …

Innate immunity is the first line of defense and is rapidly responsive to danger signals from
microbial pathogens and tissue injury. The mononuclear phagocyte system encompasses …

A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune …

A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune …

A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune …

In the present study, the authors evaluated the contributions of the CXC chemokine ligand
(CXCL) 10 to leukocyte recruitment into the central nervous system (CNS) and disease …