A single G protein–coupled receptor (GPCR) can activate multiple signaling cascades
based on the binding of different ligands. The biological relevance of this feature in immune …

Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute
encephalomyelitis followed by a chronic demyelinating disease with clinical and histological …

Immune damages on the peripheral myelin sheath under pro-inflammatory milieu result in
primary demyelination in inflammatory demyelinating neuropathy. Inflammatory cytokines …

Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …

Objective: To define the chemokine profile in the CSF of patients with multiple sclerosis (MS)
and compare it with three control groups; patients with benign headache (headache), non …

Innate immunity is the first line of defense and is rapidly responsive to danger signals from
microbial pathogens and tissue injury. The mononuclear phagocyte system encompasses …

In the present study, the authors evaluated the contributions of the CXC chemokine ligand
(CXCL) 10 to leukocyte recruitment into the central nervous system (CNS) and disease …

Chemokine CXCL12 (C‐X‐C motif chemokine ligand 12) restricts immune cell invasion of
the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune …

B cells have been implicated in the pathogenesis of multiple sclerosis, but the mechanisms
that guide B cell activation in the periphery and subsequent migration to the CNS remain …

Abstract Background Multiple Sclerosis (MS) is characterized by the pathological trafficking
of leukocytes into the central nervous system (CNS). Using the murine MS model …