The immune system specifically recognizes and eliminates foreign agents thereby protecting
the host against infection. During maturation of the immune system, immune cells that react …

The rising incidence of autoimmune diseases is straining the healthcare system's capacity to
care for patients with autoimmunity. To further compound this growing crisis, this rise occurs …

Complex autoimmune diseases are chronic conditions initiated by a loss of immunological
tolerance to self-antigens. Despite many years of intense investigation, the etiopathogenic …

In recent decades, an enormous effort has been made to elucidate the pathogenesis of
autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in …

Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding
of the immune mechanisms underlying autoimmunity and autoimmune disease has …

Autoimmune diseases are the result of specific immune responses directed against
structures of the self (Burnet and Fenner, 1949). The organism possesses powerful …

Autoimmunity refers to an organism's immune response against its own healthy cells,
tissues, or components, potentially leading to irreversible damage to vital organs. Central …

Autoimmune reactions reflect an imbalance between effector and regulatory immune
responses, typically develop through stages of initiation and propagation, and often show …

Autoimmunity refers to an inappropriate immune response against self-components of the
host that results in pathological conditions. Autoimmune diseases are characterized by an …

Autoimmune diseases are common diseases in which loss of tolerance within the immune
system results in pathologic immune responses that target either cellular or organ-specific …