Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice

IC Lee, WM Lin, JC Shu, SW Tsai… - … research Part A, 2017 - Wiley Online Library
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …

Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications

CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …

Dissolving polymer microneedles for transdermal delivery of insulin

N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …

Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity

S Kim, H Yang, J Eum, Y Ma, SF Lahiji, H Jung - Biomaterials, 2020 - Elsevier
Recently, numerous transdermal drug delivery systems have been developed for safe and
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …

Fabrication of composite microneedles integrated with insulin-loaded CaCO3 microparticles and PVP for transdermal delivery in diabetic rats

D Liu, B Yu, G Jiang, W Yu, Y Zhang, B Xu - Materials Science and …, 2018 - Elsevier
Dissolving microneedles (MNs) display high efficiency, safety and painless in transdermal
delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from …

Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin

W Yu, G Jiang, Y Zhang, D Liu, B Xu, J Zhou - Materials Science and …, 2017 - Elsevier
To reduce the inconvenient and painful of subcutaneous needle injection, the polymer
microneedle patches that fabricated from modified alginate and hyaluronate were prepared …

Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …

In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery

BZ Chen, M Ashfaq, XP Zhang, JN Zhang… - Journal of Drug …, 2018 - Taylor & Francis
Microneedles (MNs) system for transdermal drug delivery has the potential to improve
therapeutic efficacy, proving an approach that is more convenient and acceptable than …

Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery

IC Lee, YC Wu, SW Tsai, CH Chen, MH Wu - Rsc Advances, 2017 - pubs.rsc.org
Transdermal drug delivery is a convenient route to transport pharmaceuticals. However, its
application is limited to a few compounds. Microneedle (MN) patches have demonstrated a …

Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery

IC Lee, JS He, MT Tsai, KC Lin - Journal of materials chemistry B, 2015 - pubs.rsc.org
Polymer microneedles (MNs) have gained increasing attention as a minimally invasive
method for efficiently delivering drugs and vaccines in a patient-friendly manner. Herein, an …