Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications
CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …
Dissolving polymer microneedles for transdermal delivery of insulin
N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …
fabricated with various methods and materials for transdermal delivery of insulin to …
Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity
Recently, numerous transdermal drug delivery systems have been developed for safe and
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …
Fabrication of composite microneedles integrated with insulin-loaded CaCO3 microparticles and PVP for transdermal delivery in diabetic rats
Dissolving microneedles (MNs) display high efficiency, safety and painless in transdermal
delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from …
delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from …
Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin
To reduce the inconvenient and painful of subcutaneous needle injection, the polymer
microneedle patches that fabricated from modified alginate and hyaluronate were prepared …
microneedle patches that fabricated from modified alginate and hyaluronate were prepared …
Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats
MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …
In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery
Microneedles (MNs) system for transdermal drug delivery has the potential to improve
therapeutic efficacy, proving an approach that is more convenient and acceptable than …
therapeutic efficacy, proving an approach that is more convenient and acceptable than …
Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery
IC Lee, YC Wu, SW Tsai, CH Chen, MH Wu - Rsc Advances, 2017 - pubs.rsc.org
Transdermal drug delivery is a convenient route to transport pharmaceuticals. However, its
application is limited to a few compounds. Microneedle (MN) patches have demonstrated a …
application is limited to a few compounds. Microneedle (MN) patches have demonstrated a …
Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery
Polymer microneedles (MNs) have gained increasing attention as a minimally invasive
method for efficiently delivering drugs and vaccines in a patient-friendly manner. Herein, an …
method for efficiently delivering drugs and vaccines in a patient-friendly manner. Herein, an …
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