Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy
Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global
biochemical profile and provide a novel metabolism-related target to improve the therapeutic …
biochemical profile and provide a novel metabolism-related target to improve the therapeutic …
[HTML][HTML] EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma
L Yang, L Liu, Z Xu, W Liao, D Feng, X Dong, S Xu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
LMP1, which is encoded by the Epstein-Barr virus, is proposed to be one of the major
oncogenic factors involved in nasopharyngeal carcinoma (NPC). Previous studies …
oncogenic factors involved in nasopharyngeal carcinoma (NPC). Previous studies …
Activation of the FGFR1 signalling pathway by the Epstein–Barr virus‐encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal …
Non‐keratinizing nasopharyngeal carcinoma (NPC) is closely associated with Epstein–Barr
virus (EBV) infection. The EBV‐encoded latent membrane protein 1 (LMP1) is believed to …
virus (EBV) infection. The EBV‐encoded latent membrane protein 1 (LMP1) is believed to …
mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma
EBV infection of preinvasive nasopharyngeal epithelium is believed to be an initiation step
during pathogenesis of nasopharyngeal carcinoma (NPC), but the mechanisms remain …
during pathogenesis of nasopharyngeal carcinoma (NPC), but the mechanisms remain …
The role of EBV-encoded LMP1 in the NPC tumor microenvironment: from function to therapy
Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV)
infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The …
infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The …
LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma
TT Cai, SB Ye, YN Liu, J He, QY Chen, HQ Mai… - PLoS …, 2017 - journals.plos.org
Myeloid-derived suppressor cells (MDSCs) are expanded in tumor microenvironments,
including that of Epstein–Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) …
including that of Epstein–Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) …
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated …
CF Yang, LX Peng, TJ Huang, GD Yang, QQ Chu… - Cancer letters, 2014 - Elsevier
Emerging evidence confirms that cancer stem cells (CSCs) are responsible for the
chemoradioresistance of malignancies. EBV-encoded latent membrane protein 1 (LMP1) is …
chemoradioresistance of malignancies. EBV-encoded latent membrane protein 1 (LMP1) is …
EBV infection and glucose metabolism in nasopharyngeal carcinoma
To establish persistent infection in cells, viruses evolve strategies to alter host cellular
pathways to regulate cell proliferation and energy metabolism which support viral infection …
pathways to regulate cell proliferation and energy metabolism which support viral infection …
EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma
J Lu, M Tang, H Li, Z Xu, X Weng, J Li, X Yu, L Zhao… - Cancer letters, 2016 - Elsevier
We conducted this research to explore the role of latent membrane protein 1 (LMP1)
encoded by the Epstein–Barr virus (EBV) in modulating the DNA damage response (DDR) …
encoded by the Epstein–Barr virus (EBV) in modulating the DNA damage response (DDR) …
Epstein-Barr virus-encoded latent membrane protein 1 upregulates glucose transporter 1 transcription via the mTORC1/NF-κB signaling pathways
Accumulating evidence indicates that oncogenic viral protein plays a crucial role in
activating aerobic glycolysis during tumorigenesis, but the underlying mechanisms are …
activating aerobic glycolysis during tumorigenesis, but the underlying mechanisms are …
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