Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

L Xiao, ZY Hu, X Dong, Z Tan, W Li, M Tang, L Chen… - Oncogene, 2014 - nature.com
Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global
biochemical profile and provide a novel metabolism-related target to improve the therapeutic …

[HTML][HTML] EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

L Yang, L Liu, Z Xu, W Liao, D Feng, X Dong, S Xu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
LMP1, which is encoded by the Epstein-Barr virus, is proposed to be one of the major
oncogenic factors involved in nasopharyngeal carcinoma (NPC). Previous studies …

Activation of the FGFR1 signalling pathway by the Epstein–Barr virus‐encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal …

AKF Lo, CW Dawson, LS Young, CW Ko… - The Journal of …, 2015 - Wiley Online Library
Non‐keratinizing nasopharyngeal carcinoma (NPC) is closely associated with Epstein–Barr
virus (EBV) infection. The EBV‐encoded latent membrane protein 1 (LMP1) is believed to …

mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma

J Zhang, L Jia, T Liu, YL Yip, WC Tang, W Lin, W Deng… - Oncogene, 2019 - nature.com
EBV infection of preinvasive nasopharyngeal epithelium is believed to be an initiation step
during pathogenesis of nasopharyngeal carcinoma (NPC), but the mechanisms remain …

The role of EBV-encoded LMP1 in the NPC tumor microenvironment: from function to therapy

AKF Lo, CW Dawson, HL Lung, KL Wong… - Frontiers in …, 2021 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV)
infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The …

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

TT Cai, SB Ye, YN Liu, J He, QY Chen, HQ Mai… - PLoS …, 2017 - journals.plos.org
Myeloid-derived suppressor cells (MDSCs) are expanded in tumor microenvironments,
including that of Epstein–Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) …

Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated …

CF Yang, LX Peng, TJ Huang, GD Yang, QQ Chu… - Cancer letters, 2014 - Elsevier
Emerging evidence confirms that cancer stem cells (CSCs) are responsible for the
chemoradioresistance of malignancies. EBV-encoded latent membrane protein 1 (LMP1) is …

EBV infection and glucose metabolism in nasopharyngeal carcinoma

J Zhang, L Jia, CM Tsang, SW Tsao - Infectious Agents Associated …, 2017 - Springer
To establish persistent infection in cells, viruses evolve strategies to alter host cellular
pathways to regulate cell proliferation and energy metabolism which support viral infection …

EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma

J Lu, M Tang, H Li, Z Xu, X Weng, J Li, X Yu, L Zhao… - Cancer letters, 2016 - Elsevier
We conducted this research to explore the role of latent membrane protein 1 (LMP1)
encoded by the Epstein–Barr virus (EBV) in modulating the DNA damage response (DDR) …

Epstein-Barr virus-encoded latent membrane protein 1 upregulates glucose transporter 1 transcription via the mTORC1/NF-κB signaling pathways

J Zhang, L Jia, W Lin, YL Yip, KW Lo, VMY Lau… - Journal of …, 2017 - Am Soc Microbiol
Accumulating evidence indicates that oncogenic viral protein plays a crucial role in
activating aerobic glycolysis during tumorigenesis, but the underlying mechanisms are …