Zusammenfassung Die Phosphoinositol-3-OH-Kinase (PI3K) und die von ihr aktivierte
Serin/Threoninkinase Akt, auch als Proteinkinase B bekannt, sind wichtige Effektormoleküle …

Phosphatidylinositol-3 kinases, PI3Ks, constitute a lipid kinase family characterized by their
ability to phosphorylate inositol ring 3′-OH group in inositol phospholipids to generate the …

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth,
survival, motility, and metabolism. This pathway is activated by several different mechanisms …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

The human body consists of countless cells with the possibility of excessive and
uncontrolled proliferation under certain dysregulated circumstances that could cause …

AKT/PKB serine threonine kinase, a critical signaling molecule promoting cell growth and
survival pathways, is frequently dysregulated in many cancers. Although …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Survival times of patients with colorectal cancer (CRC) have increased over the past
decade, primarily as a result of treatment with combinations of conventional cytotoxic agents …

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular
processes. An overactivation of the pathway is frequently present in human malignancies …

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway play a key role in the
pathogenesis of numerous cancers by altering cellular growth, metabolism, proliferation …