Background We previously reported that impaired type I IFN activity, due to inborn errors of
TLR3-and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type …

The antibody profile against autoantigens previously associated with autoimmune diseases
and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome …

Abstract Background Interferons (IFNs) play a crucial role in antiviral immunity. Genetic
defects in interferon receptors, IFNs, and auto-antibodies against IFNs can lead to the …

A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination |
New England Journal of Medicine Skip to main content The New England Journal of …

Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening
COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination …

The relation between infections and autoimmune diseases has been extensively
investigated. Multiple studies suggest a causal relation between these two entities with …

Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated …

We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited
deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons …

Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening
disease, typically in patients with no previous history of severe viral illness. Autosomal …

The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …