[HTML][HTML] Molecular targeted therapies in hepatocellular carcinoma: from pre-clinical models to clinical trials

P Newell, A Villanueva, JM Llovet - Journal of hepatology, 2008 - Elsevier
Hepatocellular carcinoma (HCC) is one of the world's most common and deadly cancers.
Less than one-third of patients can currently benefit from potentially curative therapies in the …

Molecular targeted therapy for hepatocellular carcinoma: bench to bedside

M Kudo - Digestive diseases, 2011 - karger.com
Abstract According to the International Agency for Research on Cancer, approximately
670,000 new cases of hepatocellular carcinoma (HCC) developed in 2005, making it the fifth …

Development of molecularly targeted therapies in hepatocellular carcinoma: where do we go now?

RS Finn - Clinical Cancer Research, 2010 - AACR
Hepatocellular carcinoma (HCC), once considered an orphan disease in the West, has
become a global health concern. It is the third leading cause of cancer death worldwide, and …

Molecular targeted therapy for hepatocellular carcinoma: present status and future directions

KJ Choi, IH Baik, SK Ye, YH Lee - Biological and Pharmaceutical …, 2015 - jstage.jst.go.jp
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most lethal
neoplasm, causing an estimated 700000 deaths annually. Currently HCC has only one …

Molecularly targeted therapy for hepatocellular carcinoma

S Tanaka, S Arii - Cancer science, 2009 - Wiley Online Library
Accumulated understanding of the molecular pathways regulating cancer progression has
led to the development of novel targeted therapies. Hepatocellular carcinoma (HCC) …

Molecular targeted therapies in hepatocellular carcinoma: past, present and future

M Stotz, A Gerger, J Haybaeck, T Kiesslich… - Anticancer …, 2015 - ar.iiarjournals.org
Hepatocellular carcinoma (HCC) is an aggressive tumor and the sixth most common form of
cancer worldwide. Surgery is the gold-standard treatment for local disease and often …

Molecular targeted therapy in hepatocellular carcinoma: from biology to clinical practice and future

A Patel, W Sun - Current treatment options in oncology, 2014 - Springer
Opinion statement Hepatocellular carcinoma (HCC) is one of the most lethal cancers
globally, particularly in certain regions of the world. Although the major risk factors for HCC …

[PDF][PDF] Molecular targeted therapies in hepatocellular carcinoma

JM Llovet, J Bruix - Hepatology, 2008 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with several
genomic alterations. There is evidence of aberrant activation of several signaling cascades …

[HTML][HTML] Molecularly targeted therapy for advanced hepatocellular carcinoma-a drug development crisis?

K Thillai, P Ross, D Sarker - World journal of gastrointestinal …, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma is the fastest growing cause of cancer related death globally.
Sorafenib, a multi-targeted kinase inhibitor, is the only drug proven to improve outcomes in …

Molecular Targeted Therapy for Hepatocellular Carcinoma: Where Are We Now?

M Kudo - Liver cancer, 2015 - karger.com
Seven years have passed since sorafenib was approved as a systemic chemotherapeutic
agent that improves survival in patients with advanced hepatocellular carcinoma (HCC) …