Sepsis and septic shock lead to considerable morbidity and mortality in developed and
developing countries. Despite advances in understanding the innate immune events that …

Severe sepsis leading to shock is the principal cause of death in non-cardiac intensive care
units. This condition develops because of a dysregulation in host responses, such that the …

Development of organ dysfunction discriminates sepsis from uncomplicated infection. The
paradigm shift implicated by the new sepsis-3 definition holds that initial impairment of any …

The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical
disorders, varying with respect to the site, bacteriology, and even presence of infection and …

Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Sepsis is a leading cause of death worldwide. After initial trials modulating the
hyperinflammatory phase of sepsis failed, generations of researchers have focused on …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …