Sepsis is a significant cause of death worldwide. Although the prevailing theory of the sepsis
syndrome has been that of a condition of uncontrolled inflammation in response to infection …

A healthy body activates the immune response to target invading pathogens (ie viruses,
bacteria, fungi, and parasites) and avoid further systemic infection. The activation of …

Sepsis, the 10th leading cause of death, is the most expensive condition in the United
States. The immune response in sepsis transitions from hyperinflammatory to a …

Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Introduction Sepsis is a dysregulated host immune response due to an uncontrolled
infection. It is a leading cause of mortality in adult intensive care units globally. When the …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. 1 These dysregulated host responses underpin the clinical …

Sepsis has a complex pathophysiology in which both excessive and refractory inflammatory
responses are hallmark features. Pro-inflammatory cytokine responses during the early …

Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …

Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …

During sepsis the host's system-wide response to microbial invasion seems dysregulated.
Here we explore the diverse multiorgan transcriptional programs activated during systemic …