Molecular and cellular aspects of sepsis-induced immunosuppression
TS Wang, JC Deng - Journal of molecular medicine, 2008 - Springer
Sepsis is a significant cause of death worldwide. Although the prevailing theory of the sepsis
syndrome has been that of a condition of uncontrolled inflammation in response to infection …
syndrome has been that of a condition of uncontrolled inflammation in response to infection …
From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches
Q Hu, C Hao, S Tang - Bioscience Reports, 2020 - portlandpress.com
A healthy body activates the immune response to target invading pathogens (ie viruses,
bacteria, fungi, and parasites) and avoid further systemic infection. The activation of …
bacteria, fungi, and parasites) and avoid further systemic infection. The activation of …
Epigenetic and metabolic programming of innate immunity in sepsis
V Vachharajani, CE McCall - Innate Immunity, 2019 - journals.sagepub.com
Sepsis, the 10th leading cause of death, is the most expensive condition in the United
States. The immune response in sepsis transitions from hyperinflammatory to a …
States. The immune response in sepsis transitions from hyperinflammatory to a …
[HTML][HTML] Focus: Death: Organ dysfunction in sepsis: An ominous trajectory from infection to death
C Caraballo, F Jaimes - The Yale journal of biology and medicine, 2019 - ncbi.nlm.nih.gov
Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …
manifestations that makes it difficult to detect and treat. It is also one of the major and most …
Role of cellular events in the pathophysiology of sepsis
Introduction Sepsis is a dysregulated host immune response due to an uncontrolled
infection. It is a leading cause of mortality in adult intensive care units globally. When the …
infection. It is a leading cause of mortality in adult intensive care units globally. When the …
Immune activation in sepsis
A Conway-Morris, J Wilson… - Critical care …, 2018 - criticalcare.theclinics.com
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. 1 These dysregulated host responses underpin the clinical …
response to infection. 1 These dysregulated host responses underpin the clinical …
Epigenetics in sepsis: understanding its role in endothelial dysfunction, immunosuppression, and potential therapeutics
D Cross, R Drury, J Hill, AJ Pollard - Frontiers in immunology, 2019 - frontiersin.org
Sepsis has a complex pathophysiology in which both excessive and refractory inflammatory
responses are hallmark features. Pro-inflammatory cytokine responses during the early …
responses are hallmark features. Pro-inflammatory cytokine responses during the early …
The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?
JS Boomer, JM Green, RS Hotchkiss - Virulence, 2014 - Taylor & Francis
Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …
understanding the immune response to sepsis provide the opportunity to develop more …
Bacterial sensing, cell signaling, and modulation of the immune response during sepsis
Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …
proposed, a large amount of new information has been generated showing a much more …
Molecular signatures of sepsis: multiorgan gene expression profiles of systemic inflammation
During sepsis the host's system-wide response to microbial invasion seems dysregulated.
Here we explore the diverse multiorgan transcriptional programs activated during systemic …
Here we explore the diverse multiorgan transcriptional programs activated during systemic …