Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …

During sepsis the host's system-wide response to microbial invasion seems dysregulated.
Here we explore the diverse multiorgan transcriptional programs activated during systemic …

The sepsis syndrome is thought to occur when microbial products activate Toll-like receptors
stimulating widespread inflammation, in turn causing organ failure, shock and death …

Abbreviations: ACCP= American College of Chest Physicians; APACHE= acute physiology
and chronic health evaluation; ILl= interleukin 1; iNOS= inducible nitric oxide synthase; …

Sepsis is a common and deadly condition. Within the current model of sepsis
immunobiology, the framing of dysregulated host immune responses into proinflammatory …

Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …

Sepsis is a major health problem. The concept that sepsis mortality is the result of an
uncontrolled hyperinflammatory host response has recently been challenged. It is now …

Despite advances in the development of powerful antibiotics and intensive care unit, sepsis
is still life threatening and the mortality rate remains unchanged for the past three decades …

In recent years, extensive basic science research has led to a clear understanding of the
molecular mechanisms contributing to the pathophysiology of sepsis. Sepsis is now defined …

Sepsis is conceptually defined as life-threatening organ dysfunction that is caused by a
dysregulated host response to infection. Although there has been significant advancement …