Sepsis is a life-threatening condition that arises when the body's response to an infection
injures its own tissues and organs. Despite significant morbidity and mortality throughout the …

Severe sepsis is the leading cause of mortality in intensive care units. The limited ability of
current therapies to reduce sepsis mortality rates has fueled research efforts for the …

The often fatal sepsis syndrome is characterized by the systemic release of inflammatory
mediators, which is regulated and counterbalanced by the coordinated expression of anti …

Sepsis is conceptually defined as life-threatening organ dysfunction that is caused by a
dysregulated host response to infection. Although there has been significant advancement …

Sepsis is a state of disrupted inflammatory homeostasis that is often initiated by infection.
The development and progression of sepsis is multi-factorial, and affects the cardiovascular …

Abstract mdash;: An intact innate and acquired immune response are essential for defeating
systemic microbial infections. Recognition molecules, inflammatory cells, and the cytokines …

This common syndrome, responsible for killing hundreds of thousands of patients each year
in the United States alone [1], was defined by a consensus statement in 1992 to consist of …

Sepsis is a common clinical entity causing thousands of deaths and costing billions of
healthcare dollars annually in the US alone [1–4]. Further, sepsis and septic shock represent …

Septic shock is initiated by a systemic inflammatory response to microbial infection that
frequently leads to impaired perfusion and multiple organ failure. Because of its high risk of …

Sepsis and resulting multiple system organ failure are the leading causes of mortality in
intensive care units. Although it is generally appreciated that rampant, deregulated …