The overdue promise of short tandem repeat variation for heritability
MO Press, KD Carlson, C Queitsch - Trends in Genetics, 2014 - cell.com
Short tandem repeat (STR) variation has been proposed as a major explanatory factor in the
heritability of complex traits in humans and model organisms. However, we still struggle to …
heritability of complex traits in humans and model organisms. However, we still struggle to …
Abundant contribution of short tandem repeats to gene expression variation in humans
The contribution of repetitive elements to quantitative human traits is largely unknown. Here
we report a genome-wide survey of the contribution of short tandem repeats (STRs), which …
we report a genome-wide survey of the contribution of short tandem repeats (STRs), which …
The impact of short tandem repeat variation on gene expression
SF Fotsing, J Margoliash, C Wang, S Saini, R Yanicky… - Nature …, 2019 - nature.com
Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans.
However, genome-wide studies of the effects of STRs on gene expression thus far have had …
However, genome-wide studies of the effects of STRs on gene expression thus far have had …
[HTML][HTML] WebSTR: a population-wide database of short tandem repeat variation in humans
Short tandem repeats (STRs) are consecutive repetitions of one to six nucleotide motifs.
They are hypervariable due to the high prevalence of repeat unit insertions or deletions …
They are hypervariable due to the high prevalence of repeat unit insertions or deletions …
The landscape of human STR variation
Short tandem repeats are among the most polymorphic loci in the human genome. These
loci play a role in the etiology of a range of genetic diseases and have been frequently …
loci play a role in the etiology of a range of genetic diseases and have been frequently …
[HTML][HTML] STaRRRT: a table of short tandem repeats in regulatory regions of the human genome
Abstract Background Tandem repeats (TRs) are unstable regions commonly found within
genomes that have consequences for evolution and disease. In humans, polymorphic TRs …
genomes that have consequences for evolution and disease. In humans, polymorphic TRs …
Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for 'missing heritability'
AJ Hannan - Trends in genetics, 2010 - cell.com
A problem of 'missing heritability'has been identified following recent genome-wide
association (GWA) studies of single nucleotide polymorphisms (SNPs) associated with …
association (GWA) studies of single nucleotide polymorphisms (SNPs) associated with …
[PDF][PDF] Polymorphic short tandem repeats make widespread contributions to blood and serum traits
J Margoliash, S Fuchs, Y Li, X Zhang, A Massarat… - Cell Genomics, 2023 - cell.com
Short tandem repeats (STRs) are genomic regions consisting of repeated sequences of 1–6
bp in succession. Single-nucleotide polymorphism (SNP)-based genome-wide association …
bp in succession. Single-nucleotide polymorphism (SNP)-based genome-wide association …
Sequencing and characterizing short tandem repeats in the human genome
HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
[HTML][HTML] Characterization of genome-wide STR variation in 6487 human genomes
Y Shi, Y Niu, P Zhang, H Luo, S Liu, S Zhang… - Nature …, 2023 - nature.com
Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome.
Many STR loci have been associated with a range of human genetic disorders. However …
Many STR loci have been associated with a range of human genetic disorders. However …