The feasibility of introducing foreign genes into the genomes of cattle, goats, pigs, and
sheep has only recently been demonstrated. Studies have thus far focused on improving …

Techniques that allow modification of the mammalian genome have made a considerable
contribution to many areas of biological science. Despite these achievements, challenges …

Since the initial demonstration in 1982 of profound phenotypic effects stemming from the
expression of a single transgene, genetic engineering has revolutionized fundamental …

The notion of directly introducing new genes or otherwise directly manipulating the genotype
of an animal is conceptually straightforward and appealing because of the speed and …

At the time of the first Transgenic Animal Research Conference, the lack of knowledge about
promoter, enhancer and coding regions of genes of interest greatly hampered our efforts to …

Transgenic farm animals are attractive alternative mammalian models to rodents for the
study of developmental, genetic, reproductive and disease-related biological questions, as …

The last quarter-of-a-century has witnessed a rapid advance in the application of genetic
engineering techniques to increasingly complex organisms, from bacteria and yeasts to …

Transgenic livestock came into existence in 1985 with the production of the first transgenic
pigs and sheep (Hammer et al., 1985). Since then, various technologies have been …

Gene transfer to generate transgenic animals is used more and more to study gene
regulation and function. It is also an essential tool to prepare pharmaceuticals or pig organs …

The techniques that are used to generate transgenic livestock are inefficient and expensive.
This, coupled with the fact that most agriculturally relevant traits are complex and controlled …