The mechanistic target of rapamycin protein complex, mTORC1, has received attention in
recent years for its role in aging and neurodegenerative diseases, such as Alzheimer's …

The mammalian target of rapamycin (mTOR) and its associated cell signaling pathways
have garnered significant attention for their roles in cell biology and oncology. Interestingly …

Neurodegenerative disorders are characterized by progressive accumulation of aggregated
and misfolded proteins, brain inflammation, autophagy impairment, and metabolism …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Neurodegenerative disorders affect more than 30 million individuals throughout the world
and lead to significant disability as well as death. These statistics will increase almost …

The mammalian target of rapamycin (mTOR), the key component of the protein complexes
mTORC1 and mTORC2, plays a critical role in cellular development, tissue regeneration …

Neurodegenerative disorders affect a significant portion of the world's population leading to
either disability or death for almost 30 million individuals worldwide. One novel therapeutic …

The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling “hub” that
integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two …

The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …

Defining the multiple roles of the mechanistic (formerly'mammalian') target of rapamycin
(mTOR) signalling pathway in neurological diseases has been an exciting and rapidly …