Biosynthesis of a novel ganoderic acid by expressing CYP genes from Ganoderma lucidum in Saccharomyces cerevisiae

WF Wang, H Xiao, JJ Zhong - Applied Microbiology and Biotechnology, 2022 - Springer
Ganoderic acids (GAs), a group of highly oxygenated lanostane-type triterpenoids from the
traditional Chinese medicinal mushroom Ganoderma lucidum, possessed significant …

Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum

WF Wang, H Xiao, JJ Zhong - Biotechnology and …, 2018 - Wiley Online Library
Ganoderic acid (GA), a triterpenoid from the traditional Chinese medicinal higher fungus
Ganoderma lucidum, possesses antitumor and other significant pharmacological activities …

Bioconversion of a ganoderic acid 3-hydroxy-lanosta-8, 24-dien-26-oic acid by a crude enzyme from Ganoderma lucidum

S Cai, H Xiao, X Wang, S Lin, JJ Zhong - Process Biochemistry, 2020 - Elsevier
Ganoderic acids (GAs) are oxygenated lanostane-type triterpenoids from the traditional
medicinal mushroom Ganoderma lucidum and of significant biological activities. Although a …

Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast

C Yang, W Li, C Li, Z Zhou, Y Xiao, X Yan - Phytochemistry, 2018 - Elsevier
Ganoderic acids, a group of oxygenated lanostane-type triterpenoids, are the major
bioactive compounds produced by the well-known medicinal macro fungus Ganoderma …

Biotechnological production and application of ganoderic acids

JW Xu, W Zhao, JJ Zhong - Applied microbiology and biotechnology, 2010 - Springer
Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are
important bioactive constituents of the famous medicinal mushroom Ganoderma lucidum …

Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 …

X Lan, W Yuan, M Wang, H Xiao - Biotechnology and …, 2019 - Wiley Online Library
Abstract Ganoderic acid 3‐hydroxy‐lanosta‐8, 24‐dien‐26‐oic acid (GA‐HLDOA), an
antitumor triterpenoid from the traditional Chinese medicinal higher fungus Ganoderma …

[HTML][HTML] Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum

Y Du, L Tian, Y Wang, Z Li, Z Xu - Chinese Medicine, 2024 - Springer
Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both
medicine and food. Ganoderic acids (GAs), the distinctive triterpenoids found in the …

[HTML][HTML] Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast

W Yuan, C Jiang, Q Wang, Y Fang, J Wang… - Nature …, 2022 - nature.com
Type II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma
are a group of triterpenoids with superior biological activities. However, challenges in the …

Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids

JW Xu, JJ Zhong - Bioengineered, 2015 - Taylor & Francis
Ganoderma lucidum is a well-known traditional medicinal mushroom that produces
ganoderic acids with numerous interesting bioactivities. Genetic engineering is an efficient …

[HTML][HTML] A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis

TS Chang, CM Chiang, YH Kao, JY Wu, YW Wu… - Molecules, 2019 - mdpi.com
Ganoderic acid A (GAA) is a bioactive triterpenoid isolated from the medicinal fungus
Ganoderma lucidum. Our previous study showed that the Bacillus subtilis ATCC (American …