Histone deacetylase inhibitors (HDACIs) are a new class of chemotherapeutic drugs able to
induce tumor cell apoptosis and/or cell cycle arrest; however, the molecular mechanisms …

Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin
remodeling and have crucial roles in numerous biological processes, largely through their …

Histone deacetylase (HDAC) inhibitors can induce programmed cell death in cancer cells,
although the underlying mechanism is obscure. In this study, we show that two distinct …

Histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA),
are targeted anticancer agents that have significant anticancer activity at doses well …

Histone deacetylase (HDAC) inhibitors have attracted much interest because of their ability
to arrest cell growth, induce cell differentiation, and in some cases, induce apoptosis of …

Histone deacetylase activity is potently inhibited by hydroaximc acid derivatives such as
suberoylanilide hydroxamic acid (SAHA) and trichostatin-A (TSA). These inhibitors …

It has been shown that epigenetic modifications play an important role in tumorigenesis.
Thus, affecting epigenetic tumorigenic alterations can represent a promising strategy for …

Anomalous gene regulation, dictated by epigenetic modifications, is a universal
characteristic of cancer cells. Histone deacetylases (HDACs) are an important class of …

Epigenic modifications, mainly DNA methylation and acetylation, are recognized as the main
mechanisms contributing to the malignant phenotype. Acetylation and deacetylation are …

Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene
expression by catalyzing the removal of acetyl groups, stimulating chromatin condensation …