Interactions of antimicrobial peptides with Leishmania and trypanosomes and their functional role in host parasitism

BS McGwire, MM Kulkarni - Experimental parasitology, 2010 - Elsevier
Antimicrobial peptides (AMPs) are multifunctional components of the innate systems of both
insect and mammalian hosts of the pathogenic trypanosomatids Leishmania and …

Antimicrobial peptides (AMPs): potential therapeutic strategy against trypanosomiases?

M Rojas-Pirela, U Kemmerling, W Quiñones… - Biomolecules, 2023 - mdpi.com
Trypanosomiases are a group of tropical diseases that have devastating health and socio-
economic effects worldwide. In humans, these diseases are caused by the pathogenic …

Antimicrobial peptide action on parasites

M Torrent, D Pulido, L Rivas, D Andreu - Current drug targets, 2012 - ingentaconnect.com
Diseases caused by protozoan parasites can pose a severe thread to human health and are
behind some serious neglected tropical diseases like malaria and leishmaniasis. Though …

[HTML][HTML] Amphibian antimicrobial peptides and Protozoa: lessons from parasites

L Rivas, JR Luque-Ortega, D Andreu - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Antimicrobial peptides (AMPs) from amphibians and other eukaryotes recognize
pathogenicity patterns mostly related to differences in membrane composition between the …

Insect antimicrobial peptides act synergistically to inhibit a trypanosome parasite

M Marxer, V Vollenweider… - … Transactions of the …, 2016 - royalsocietypublishing.org
The innate immune system provides protection from infection by producing essential effector
molecules, such as antimicrobial peptides (AMPs) that possess broad-spectrum activity. This …

Therapeutic potential of antimicrobial peptides against pathogenic protozoa

CL Hagemann, AJ Macedo, T Tasca - Parasitology Research, 2024 - Springer
Protozoal infections cause significant morbidity and mortality in humans and animals. The
use of several antiprotozoal drugs is associated with serious adverse effects and resistance …

Characterization of the leishmanicidal activity of antimicrobial peptides

JR Luque-Ortega, L Rivas - Antimicrobial Peptides: Methods and Protocols, 2010 - Springer
This chapter describes the basic methodology to assay the activity of antimicrobial peptides
(AMPs) on Leishmania, a human protozoan parasite. The protocols included can be …

Antimicrobial peptides: On future antiprotozoal and anthelminthic applications

K Nogrado, P Adisakwattana, O Reamtong - Acta Tropica, 2022 - Elsevier
Control and elimination of parasitic diseases are nowadays further complicated by
emergence of drug resistance. Drug resistance is a serious threat as there are not many …

Activity of Anti-Microbial Peptides (AMPs) against Leishmania and Other Parasites: An Overview

R El-Dirany, H Shahrour, Z Dirany, F Abdel-Sater… - Biomolecules, 2021 - mdpi.com
Anti-microbial peptides (AMPs), small biologically active molecules, produced by different
organisms through their innate immune system, have become a considerable subject of …

The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum

M Tonk, C Pierrot, A Cabezas-Cruz… - Parasitology …, 2019 - Springer
Antimicrobial peptides (AMPs) are important components of the vertebrate and invertebrate
innate immune systems. Although AMPs are widely recognized for their broad-spectrum …